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Treatment of Acute T-Cell Mediated Rejection

Treatment depends on classification on histology and the clinical status of patient.

Acute T-Cell Medicated Rejection (Acute Cellular rejection)

1. Type IA or IB acute cellular rejection (no evidence of vascular or antibody-mediated rejection)

  • Methylprednisolone 500mg IV daily for 3 doses
  • Consider ATG if steroid resistant cellular rejection

2. Type IIA, IIB ORĀ  vascular rejection

  • Methylprednisolone 500mg IV daily for 3 doses
  • ATG treatment dosing (see protocol below)