{"id":1558,"date":"2018-09-12T11:57:19","date_gmt":"2018-09-12T11:57:19","guid":{"rendered":"http:\/\/edren.org\/ren\/?page_id=1558"},"modified":"2024-06-11T12:45:38","modified_gmt":"2024-06-11T12:45:38","slug":"tacrolimus-levels","status":"publish","type":"page","link":"https:\/\/edren.org\/ren\/handbook\/transplant-handbook\/immunosuppression-protocol\/tacrolimus-levels\/","title":{"rendered":"Tacrolimus levels"},"content":{"rendered":"<p>Acceptable ranges of trough (12 hour) tacrolimus levels may be wide, and general principles dictate that levels should be higher early on, and in those with high immunological risk. However, many factors such as drug adverse effects, dose of MMF, infectious risk, and prior clinical events also influence the target range.<\/p>\n<table style=\"border-collapse: collapse; width: 73.1995%;\" border=\"1\">\n<tbody>\n<tr>\n<td style=\"width: 19.9702%;\"><\/td>\n<td style=\"width: 24.3693%; background-color: #e6f7ed; text-align: center;\"><strong><span style=\"color: #993300;\">Standard Risk<\/span><\/strong><\/td>\n<td style=\"width: 28.7919%; background-color: #e6f7ed; text-align: center;\"><strong><span style=\"color: #993300;\">High Risk<\/span><\/strong><\/td>\n<\/tr>\n<tr style=\"border-style: solid; border-color: #993300;\">\n<td style=\"width: 19.9702%; background-color: #e6f7ed; text-align: right;\"><strong><span style=\"color: #993300;\">Month 1<\/span><\/strong><\/td>\n<td style=\"width: 53.1612%; text-align: center;\" colspan=\"2\">7 &#8211; 10<\/td>\n<\/tr>\n<tr style=\"border-style: solid; border-color: #993300;\">\n<td style=\"width: 19.9702%; background-color: #e6f7ed; text-align: right;\"><strong><span style=\"color: #993300;\">Month 2 &#8211; 3<\/span><\/strong><\/td>\n<td style=\"width: 53.1612%; text-align: center;\" colspan=\"2\">6 &#8211; 9<\/td>\n<\/tr>\n<tr style=\"border-style: solid; border-color: #993300;\">\n<td style=\"width: 19.9702%; background-color: #e6f7ed; text-align: right;\"><strong><span style=\"color: #993300;\">Month &gt;3<\/span><\/strong><\/td>\n<td style=\"width: 53.1612%; text-align: center;\" colspan=\"2\">4 &#8211; 8<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Lower risk patients will usually be set target levels towards the lower end of the range, and higher risk towards the upper end.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Acceptable ranges of trough (12 hour) tacrolimus levels may be wide, and general principles dictate that levels should be higher early on, and in those with high immunological risk. However, many factors such as drug adverse effects, dose of MMF, infectious risk, and prior clinical events also influence the target\u2026<\/p>\n<p> <a class=\"continue-reading-link\" href=\"https:\/\/edren.org\/ren\/handbook\/transplant-handbook\/immunosuppression-protocol\/tacrolimus-levels\/\"><span>Continue reading<\/span><i class=\"crycon-right-dir\"><\/i><\/a> <\/p>\n","protected":false},"author":2,"featured_media":0,"parent":1550,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_lmt_disableupdate":"no","_lmt_disable":"","footnotes":""},"class_list":["post-1558","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/pages\/1558","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/comments?post=1558"}],"version-history":[{"count":5,"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/pages\/1558\/revisions"}],"predecessor-version":[{"id":6445,"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/pages\/1558\/revisions\/6445"}],"up":[{"embeddable":true,"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/pages\/1550"}],"wp:attachment":[{"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/media?parent=1558"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}