{"id":1590,"date":"2018-09-12T13:39:21","date_gmt":"2018-09-12T13:39:21","guid":{"rendered":"http:\/\/edren.org\/ren\/?page_id=1590"},"modified":"2019-06-27T11:00:32","modified_gmt":"2019-06-27T11:00:32","slug":"azathioprine","status":"publish","type":"page","link":"https:\/\/edren.org\/ren\/handbook\/transplant-handbook\/immunosuppressive-drugs\/azathioprine\/","title":{"rendered":"Azathioprine"},"content":{"rendered":"<p><strong><span style=\"font-family: georgia, palatino, serif; color: #993300;\">Current indication:<\/span><\/strong><\/p>\n<p><span style=\"font-family: georgia, palatino, serif;\">For use in patients who are unable to tolerate mycophenolate mofetil.<\/span><\/p>\n<p><strong><span style=\"font-family: georgia, palatino, serif; color: #993300;\">Dose:<\/span><\/strong><\/p>\n<ul style=\"list-style-type: disc;\">\n<li><strong><em><span style=\"font-family: georgia, palatino, serif; color: #993300;\">Initial &#8211;\u00a0<\/span><\/em><\/strong><span style=\"font-family: georgia, palatino, serif;\">1-2 mg\/kg once daily.<\/span><\/li>\n<li><strong><em><span style=\"font-family: georgia, palatino, serif; color: #993300;\">Maintenance &#8211;\u00a0<\/span><\/em><\/strong><span style=\"font-family: georgia, palatino, serif;\">1 mg\/kg once daily.<\/span><\/li>\n<li><span style=\"color: #993300;\"><strong><em><span style=\"font-family: georgia, palatino, serif;\"><span style=\"color: #993300;\">Monitoring\u00a0 &#8211; <\/span><\/span><\/em><\/strong><\/span><span style=\"font-family: georgia, palatino, serif;\">No monitoring of drug levels is required.<\/span><\/li>\n<\/ul>\n<p><strong><span style=\"font-family: georgia, palatino, serif; color: #993300;\">Preparation:<\/span><\/strong><\/p>\n<p><span style=\"font-family: georgia, palatino, serif;\"><span style=\"color: #993300;\">Azathioprine<\/span> is available as 25 mg and 50 mg tablets. There are both generic and brand (Imuran) forms on the market.<\/span><\/p>\n<p><strong><span style=\"font-family: georgia, palatino, serif; color: #993300;\">Administration:<\/span><\/strong><\/p>\n<p><span style=\"font-family: georgia, palatino, serif;\">Virtually exclusively oral although an IV preparation is available.<\/span><\/p>\n<p><strong><span style=\"font-family: georgia, palatino, serif; color: #993300;\">Contra-indications:<\/span><\/strong><\/p>\n<ul style=\"list-style-type: disc;\">\n<li>Pregnancy.<\/li>\n<li><span style=\"font-family: georgia, palatino, serif;\">Bone marrow dysfunction, i.e. patients who are known to be leucopaenic or thrombocytopaenic.<\/span><\/li>\n<li><span style=\"font-family: georgia, palatino, serif;\">Reduce dose if hepatic dysfunction is present.<\/span><\/li>\n<\/ul>\n<p><strong><span style=\"font-family: georgia, palatino, serif; color: #993300;\">Drug interactions:<\/span><\/strong><\/p>\n<p><span style=\"font-family: georgia, palatino, serif;\">Allopurinol and Febuxostat must not be co-prescribed as an inhibition of xanthine oxidase results in potentially fatal accumulation of azathioprine and its metabolites. An alternative uricosuric- benzbromarone is available on a named patient basis. Contact transplant unit pharmacist for further details.<\/span><\/p>\n<p><strong><span style=\"font-family: georgia, palatino, serif; color: #993300;\">Side Effects:<\/span><\/strong><\/p>\n<ul style=\"list-style-type: disc;\">\n<li><span style=\"font-family: georgia, palatino, serif;\">Bone marrow suppression &#8211; usually reversible following cessation.<\/span><\/li>\n<li><span style=\"font-family: georgia, palatino, serif;\">Cholestatis and disturbed liver function &#8211; again usually reversible.<\/span><\/li>\n<li><span style=\"font-family: georgia, palatino, serif;\">Pancreatitis<\/span><\/li>\n<\/ul>\n<p><span style=\"font-family: georgia, palatino, serif;\">Dose may require to be altered depending on WCC, ie. reduce if WCC&lt;4.0, stop if WCC &lt;3.0 and re-introduce at a lower doses when WCC&gt;3.0.<\/span><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Current indication: For use in patients who are unable to tolerate mycophenolate mofetil. Dose: Initial &#8211;\u00a01-2 mg\/kg once daily. Maintenance &#8211;\u00a01 mg\/kg once daily. Monitoring\u00a0 &#8211; No monitoring of drug levels is required. Preparation: Azathioprine is available as 25 mg and 50 mg tablets. There are both generic and brand\u2026<\/p>\n<p> <a class=\"continue-reading-link\" href=\"https:\/\/edren.org\/ren\/handbook\/transplant-handbook\/immunosuppressive-drugs\/azathioprine\/\"><span>Continue reading<\/span><i class=\"crycon-right-dir\"><\/i><\/a> <\/p>\n","protected":false},"author":2,"featured_media":0,"parent":1568,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"class_list":["post-1590","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/pages\/1590","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/comments?post=1590"}],"version-history":[{"count":2,"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/pages\/1590\/revisions"}],"predecessor-version":[{"id":3027,"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/pages\/1590\/revisions\/3027"}],"up":[{"embeddable":true,"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/pages\/1568"}],"wp:attachment":[{"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/media?parent=1590"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}