{"id":223,"date":"2018-04-23T13:22:02","date_gmt":"2018-04-23T13:22:02","guid":{"rendered":"http:\/\/edren.org\/ren\/?page_id=223"},"modified":"2024-07-01T13:34:24","modified_gmt":"2024-07-01T13:34:24","slug":"acute-renal-failure-aki","status":"publish","type":"page","link":"https:\/\/edren.org\/ren\/edren-info\/acute-renal-failure-aki\/","title":{"rendered":"Acute renal failure (AKI)"},"content":{"rendered":"<p>Acute Renal Failure (ARF), or Acute Kidney Injury (AKI) is when the kidneys suddenly stop working properly.\u00a0 This can be partial or complete. \u00a0If it is complete, you can&#8217;t live for very long without some kind of treatment.<\/p>\n<h5><strong><span style=\"color: #993300;\">What causes ARF\/AKI?<\/span><\/strong><\/h5>\n<ul style=\"list-style-type: disc;\">\n<li><strong><span style=\"color: #993300;\">Pre-renal <\/span><\/strong>&#8211; things that reduce the blood supply to the kidney.\u00a0 For example dehydration, or low blood pressure from other causes such as bleeding, heart failure, severe infectiion.\u00a0 More likely in the presence of some medicines, such as ACE inhibitors, or non-steroidal anti-inflammatory drugs (NSAIDs), or diuretics.\u00a0 Replacing fluid with IV fluids, and using other treatments to improve the circulation, may help.<\/li>\n<li><strong><span style=\"color: #993300;\">Renal <\/span><\/strong>&#8211; toxins or diseases affecting the kidney.\u00a0 This is the rarest type of ARF, but if it looks likely, a kidney biopsy is often necessary to sort out the exact cause.<\/li>\n<li><strong><span style=\"color: #993300;\">Post-renal<\/span><\/strong> &#8211; things that block the flow of urine, for example blockages in the ureters or bladder or prostate.\u00a0 It&#8217;s important to spot these so that the obstruction can be relieved, and then with luck kidney function should improve rapidly. Ultrasound or other imaging tests usually show that urine outflow is obstructed.\u00a0 More on obstruction.<\/li>\n<\/ul>\n<h5><strong><span style=\"color: #993300;\">Established ARF\/AKI &#8211; acute tubular necrosis<\/span><\/strong><\/h5>\n<p>Established ARF that cannot be reversed by getting fluids right or removing toxins because the damage is too severe or the problem too long-lasting. \u00a0This often puts the kidney into a state of &#8216;hibernation&#8217; during which very little urine is produced.\u00a0 Under the microscope at this time the tubules of each nephron look sick and this appearance is called Acute Tubular Necrosis, or ATN.<\/p>\n<p>This is the commonest cause of acute renal failure in patients referred to renal units for dialysis for ARF\/AKI.\u00a0 You usually just have to sit it out until the kidneys recover. \u00a0This may take days to weeks. During that time, careful monitoring of fluids and diet is required, and temporary support by dialysis is often necessary, to give time for the kidneys to recover. Nothing is yet know to speed up recovery.\u00a0<\/p>\n<p>Dialysis (removal of toxins from blood) may be necessary when<\/p>\n<ul style=\"list-style-type: disc;\">\n<li>Potassium or other toxins build up to dangerous levels in the blood<\/li>\n<li>There is fluid (salt and water) overload, causing breathlessness or severe oedema (swelling)<\/li>\n<li>There are other severe symptoms<\/li>\n<\/ul>\n<p>When AKI is prolonged, infections and malnutrition can be serious problems.<\/p>\n<h5><strong><span style=\"color: #993300;\">Diagnosing the cause<\/span><\/strong><\/h5>\n<p>Often it is obvious, because the AKI occurs at a time of severe illness. \u00a0However<\/p>\n<ul style=\"list-style-type: disc;\">\n<li>Talking to the patient, finding what drugs they&#8217;ve been given, and what has happened during the illness are important.\u00a0 Old blood test results are valuable.<\/li>\n<li>Ultrasound or other imaging will usually rule out (or prove) obstruction, and show whether the kidneys are a normal size. Small kidneys suggest previous kidney disease. Damaged kidneys are more likely to develop AKI.<\/li>\n<li>Urine testing is important to look for infection, or signs of kidney inflammation.<\/li>\n<li>A range of special tests may be valuable when the cause isn&#8217;t obvious.<\/li>\n<li>Kidney biopsy is valuable in a minority of patients.<\/li>\n<\/ul>\n<h5><strong><span style=\"color: #993300;\">What are the treatments<\/span><\/strong><\/h5>\n<h6><strong><span style=\"color: #993300;\">General care and to replace kidney function<\/span><\/strong><\/h6>\n<ul style=\"list-style-type: disc;\">\n<li>Careful monitoring of fluid intake and output, diet, drugs, prevention of infections.<\/li>\n<li>Dialysis via haemodialysis machines &#8211; may be given every day or less often.<\/li>\n<li>Continuous blood purification treatments &#8211; such as continuous dialysis or haemofiltration, may be given, especially on intensive care units. \u00a0These don&#8217;t necessarily work better, but can be easier in patients who are critically ill.<\/li>\n<li>Peritoneal dialysis &#8211; can be used, but in developed countries is less often used for AKI these days.<\/li>\n<\/ul>\n<h6><strong><span style=\"color: #993300;\">Treatments for the cause<\/span><\/strong><\/h6>\n<ul style=\"list-style-type: disc;\">\n<li><strong><span style=\"color: #993300;\">Obstruction<\/span><\/strong> &#8211; relief of the blockage usually makes the situation much better.<\/li>\n<li><strong><span style=\"color: #993300;\">Pre-renal<\/span><\/strong> &#8211; once ATN is established, there is no treatment that is proven to speed recovery, but early treatment with fluids etc may help this developing.<\/li>\n<li><strong><span style=\"color: #993300;\">Renal<\/span><\/strong> &#8211; some causes benefit from urgent treatment. \u00a0Examples include:<\/li>\n<\/ul>\n<p style=\"padding-left: 60px;\"><a href=\"http:\/\/edren.org\/ren\/edren-info\/interstitial-nephritis\/\" data-cke-saved-href=\"[wblink177]\">Acute interstitial nephritis<\/a><br \/><a href=\"http:\/\/edren.org\/ren\/edren-info\/crescentic-nephritis-rpgn\/\" data-cke-saved-href=\"[wblink134]\">Crescentic nephritis<\/a><br \/><a href=\"http:\/\/edren.org\/ren\/edren-info\/glomerulonephritis\/\" data-cke-saved-href=\"[wblink223]\">Glomerulonephritis<\/a> &#8211; may need special treatments too<\/p>\n<h5><strong><span style=\"color: #993300;\">Will any damage remain?<\/span><\/strong><\/h5>\n<p>Although many people recover almost completely from AKI, some are left with some kidney scarring and reduced kidney function.\u00a0\u00a0This depends on the cause and the severity, and how young and fit you are when it happens.<\/p>\n<p>A small proportion of people don&#8217;t recover and end up with <a href=\"http:\/\/edren.org\/ren\/edren-info\/dialysis-and-endstage-renal-failure\/\" data-cke-saved-href=\"[wblink135]\">end-stage renal failure<\/a>. \u00a0This is unusual.<\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<p><span style=\"font-size: 12pt;\"><strong><span style=\"color: #999999;\">Acknowledgements: <\/span><\/strong><span style=\"color: #999999;\">The authors of this page were Neil Turner and Caroline Whitworth. It was first published in 2010. The date it was last modified is shown in the footer.<\/span><\/span><\/p>\n\n\n<p><a href=\"http:\/\/edren.org\/ren\/wp-admin\/post.php?post=223&amp;action=edit\">Edit Page<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Acute Renal Failure (ARF), or Acute Kidney Injury (AKI) is when the kidneys suddenly stop working properly.\u00a0 This can be partial or complete. \u00a0If it is complete, you can&#8217;t live for very long without some kind of treatment. What causes ARF\/AKI? Pre-renal &#8211; things that reduce the blood supply to\u2026<\/p>\n<p> <a class=\"continue-reading-link\" href=\"https:\/\/edren.org\/ren\/edren-info\/acute-renal-failure-aki\/\"><span>Continue reading<\/span><i class=\"crycon-right-dir\"><\/i><\/a> <\/p>\n","protected":false},"author":2,"featured_media":0,"parent":220,"menu_order":137,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"class_list":["post-223","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/pages\/223","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/comments?post=223"}],"version-history":[{"count":69,"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/pages\/223\/revisions"}],"predecessor-version":[{"id":2840,"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/pages\/223\/revisions\/2840"}],"up":[{"embeddable":true,"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/pages\/220"}],"wp:attachment":[{"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/media?parent=223"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}