{"id":5349,"date":"2021-01-29T13:08:11","date_gmt":"2021-01-29T13:08:11","guid":{"rendered":"https:\/\/edren.org\/ren\/?page_id=5349"},"modified":"2023-04-03T14:10:11","modified_gmt":"2023-04-03T14:10:11","slug":"hyperkalaemia-outpatient","status":"publish","type":"page","link":"https:\/\/edren.org\/ren\/handbook\/unithdbk\/fluids-and-electrolytes\/hyperkalaemia-outpatient\/","title":{"rendered":"Hyperkalaemia (outpatient)"},"content":{"rendered":"<h1><strong>Hyperkalaemia in the community<\/strong><\/h1>\n<p>Hyperkalaemia detected in the community is a frequent reason for referral to secondary care.\u00a0 These pages are designed to assist decision-making in primary care.\u00a0 We also have guidance on <a href=\"https:\/\/edren.org\/ren\/handbook\/unithdbk\/hyperkalaemia\/\">management of hyperkalaemia in hospital<\/a>.<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>Expert guidelines<\/strong><\/h3>\n<p>1) <a href=\"https:\/\/renal.org\/sites\/renal.org\/files\/RENAL%20ASSOCIATION%20HYPERKALAEMIA%20GUIDELINE%202020.pdf\"><em>Treatment of acute hyperkalaemia in adults (July 2020)<\/em><\/a>: the UK Renal Association Clinical Practice Guideline.\u00a0 This gives very comprehensive advice on hyperkalaemia (is 161 pages long).\u00a0 The flow-chart on p156 on &#8220;Management of Hyperkalaemia in the Community&#8221; recommends a simple management algorithm.<\/p>\n<p><span style=\"font-family: 'Source Sans Pro';\">2) \u2018<\/span><a href=\"https:\/\/heart.bmj.com\/content\/heartjnl\/105\/12\/904.full.pdf\"><em>Change in renal function associated with drug treatment in heart failure: national\u00a0guidance (January 2019)<\/em><\/a><em>\u2019<\/em> . These joint cardiology-renal guidelines specifically address patients with heart failure (in whom there may be a strong rationale to continue renin-angiotensin inhibitors).\u00a0 Table 2 gives a suggested management algorithm.<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>Our recommendations for the <\/strong><strong>management of hyperkalaemia in primary care:<\/strong><\/h3>\n<p>Based on our experience of referrals from primary care, we have used the relevant recommendations from these expert guidelines to help answer the most commonly asked questions:<\/p>\n<ol>\n<li><em>Should this patient come to hospital for assessment and treatment?<\/em><\/li>\n<li><em>If they don\u2019t need to come to hospital, when should the potassium be re-checked?<\/em><\/li>\n<li><em>Should renin-angiotensin-aldosterone system inhibitors be stopped? <\/em><\/li>\n<li><em>What other factors should be addressed to prevent recurrence?<\/em><\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<h5><strong>Suggested management algorithm:<\/strong><\/h5>\n<p><a href=\"https:\/\/edren.org\/ren\/wp-content\/uploads\/2023\/04\/HyperK-outpatient.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-6086\" src=\"https:\/\/edren.org\/ren\/wp-content\/uploads\/2023\/04\/HyperK-outpatient.png\" alt=\"\" width=\"1127\" height=\"1736\" srcset=\"https:\/\/edren.org\/ren\/wp-content\/uploads\/2023\/04\/HyperK-outpatient.png 1127w, https:\/\/edren.org\/ren\/wp-content\/uploads\/2023\/04\/HyperK-outpatient-195x300.png 195w, https:\/\/edren.org\/ren\/wp-content\/uploads\/2023\/04\/HyperK-outpatient-665x1024.png 665w, https:\/\/edren.org\/ren\/wp-content\/uploads\/2023\/04\/HyperK-outpatient-768x1183.png 768w, https:\/\/edren.org\/ren\/wp-content\/uploads\/2023\/04\/HyperK-outpatient-997x1536.png 997w, https:\/\/edren.org\/ren\/wp-content\/uploads\/2023\/04\/HyperK-outpatient-97x150.png 97w\" sizes=\"auto, (max-width: 1127px) 100vw, 1127px\" \/><\/a><\/p>\n<p>Most patients requiring urgent assessment in hospital should be referred to acute medicine or the emergency department using standard referral pathways.\u00a0 (Patients with pre-existing advanced CKD or heart failure may referred to the nephrology or cardiology teams but will often have to be admitted <em>via<\/em> acute medicine.)<\/p>\n<p>&nbsp;<\/p>\n<h5><strong>Notes and rationale:<\/strong><\/h5>\n<p>The most important principles are:<\/p>\n<ul style=\"list-style-type: disc;\">\n<li>the risk factors for hyperkalaemia are renal failure (AKI or CKD), RASi, potassium-sparing diuretics, heart failure, diabetes and adrenal insufficiency<\/li>\n<li>therefore dangerous hyperkalaemia is almost never encountered in patients with normal renal and adrenal function who are not taking renin-angiotensin-aldosterone inhibitors (RAASi) or potassium-sparing diuretics<\/li>\n<li>patients with heart failure with reduced ejection fraction (HFrEF) and diabetic kidney disease with heavy albuminuria (uACR &gt; 30 mg\/mmol) stand to benefit a lot from ACEi\/ARBs and therefore it may be worth deploying strategies to allow these medications to be continued (e.g. dietary K restriction, K binders, co-prescription of loop or thiazide diuretics)<\/li>\n<li>patients with other proteinuric kidney disease (e.g. diabetes and uACR &gt; 3 mg\/mmol or no diabetes and uACR &gt; 30), vascular disease and stroke are also likely to benefit from ACEi\/ARBs but to a lesser extent (i.e. the NNT to prevent important outcomes will be higher than in HFrEF and diabetic nephropathy)<\/li>\n<li>have a low threshold for discussing with the relevant team in secondary care (e.g. heart failure team or renal team)<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>Drugs that can predispose to hyperkalaemia include:<\/p>\n<ul>\n<li>RAASi: including ACE inhibitors (ACEi), angiotensin receptor antagonists (ARBs), angiotensin receptor-neprilysin inhibitors (ARNI) and mineralocorticoid receptor antagonists (MRA)<\/li>\n<li>potassium-sparing diuretics (e.g. amiloride \/ spironolactone)<\/li>\n<li>trimethoprim (also in co-trimoxazole)<\/li>\n<li>non-selective beta-blockers<\/li>\n<li>heparin<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>Our guidance on the use of sodium zirconium cyclosilicate (Lokelma) is given <a href=\"https:\/\/edren.org\/ren\/handbook\/unithdbk\/prescribing\/renal-drugs-a-z\/\">here<\/a>.\u00a0 Patients may be eligible if they have CKD3B or worse, significant proteinuria (uPCR &gt; 50 mg\/mmol) and attend a renal outpatient clinic.\u00a0 Lokelma may then be prescribed to facilitate use of RAASi; there are defined criteria in the guideance for determining whether hyperkalaemia is currently preventing RAASi from being used at therapeutic doses.<\/p>\n<p>Advice on dietary potassium restriction can be found <a href=\"https:\/\/edren.org\/ren\/edren-info\/diet-in-renal-disease\/#Potassium\">here<\/a>.<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>Acknowledgements<\/strong><\/h3>\n<p>This page was first written by Tariq Farrah (January 2021).\u00a0 Date and time of most recent edit is shown in the footer.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hyperkalaemia in the community Hyperkalaemia detected in the community is a frequent reason for referral to secondary care.\u00a0 These pages are designed to assist decision-making in primary care.\u00a0 We also have guidance on management of hyperkalaemia in hospital. &nbsp; Expert guidelines 1) Treatment of acute hyperkalaemia in adults (July 2020):\u2026<\/p>\n<p> <a class=\"continue-reading-link\" href=\"https:\/\/edren.org\/ren\/handbook\/unithdbk\/fluids-and-electrolytes\/hyperkalaemia-outpatient\/\"><span>Continue reading<\/span><i class=\"crycon-right-dir\"><\/i><\/a> <\/p>\n","protected":false},"author":6,"featured_media":0,"parent":5374,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_lmt_disableupdate":"no","_lmt_disable":"","footnotes":""},"class_list":["post-5349","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/pages\/5349","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/comments?post=5349"}],"version-history":[{"count":11,"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/pages\/5349\/revisions"}],"predecessor-version":[{"id":6087,"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/pages\/5349\/revisions\/6087"}],"up":[{"embeddable":true,"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/pages\/5374"}],"wp:attachment":[{"href":"https:\/\/edren.org\/ren\/wp-json\/wp\/v2\/media?parent=5349"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}