It is now known that about 1 in 100 people carry an Alport gene variant (‘mutation’) that could cause disease, but it is inherited with a second normal copy. While most people who have this remain well, a minority do develop kidney disease. The lifetime risk of developing kidney disease is definitely increased, but only a small minority run into serious trouble, and it us usually (but not always) in later life.<\/p>\n
We need to learn more about what makes kidney disease more likely in people with this – is it other genes you inherit, or things that happen to you?<\/p>\n
This has led to the concept of a spectrum of Alport-related disease. It overlaps with Thin Basement Membrane<\/a> Nephropathy\/Disease. See figure below.<\/p>\n Figure:<\/p>\n","protected":false},"excerpt":{"rendered":" It is now known that about 1 in 100 people carry an Alport gene variant (‘mutation’) that could cause disease, but it is inherited with a second normal copy. While most people who have this remain well, a minority do develop kidney disease. The lifetime risk of developing kidney disease\u2026<\/p>\n